Cerebellar neurodegeneration in phospholipid flippases ATP8A1/ATP8A2 double knock-out mice can be ameliorated by inactivating a microglial PS receptor
Shu Tokunaga, Yuta Umemura, Muneyuki Kawase, Tsuzumi Nakajima, Mana Kato, Chiharu Miyajima, Hisashi Oishi, Mitsuharu Hattori · FENS Forum 2024
Phospholipids are asymmetrically distributed across the plasma membrane. Phosphatidylserine (PS) is concentrated on the cytoplasmic leaflet of the lipid bilayer, but it is externalized in various situations. In the central nervous system, microglia and astrocytes recognize externalized PS on the neuronal plasma membrane. To maintain the PS asymmetry, flippases translocate PS from the exoplasmic leaflet to the cytoplasmic leaflet. Among all flippases, ATP8A1 and ATP8A2 are most abundantly expressed in the neurons in the brain. Genetic defects of ATP8A2 gene in humans cause severe disequilibrium
ePoster · Neuroscience