Topic: I150V mutation

N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors found ubiquitously in the nervous system. Mutations in genes encoding NMDARs are associated with a broad range of neurological and psychiatric disorders, but their causes at the protein level remain elusive. To study the structural changes in NMDARs caused by disease-associated mutations we employed single-molecule FRET, a technique that allows us to observe conformational changes in real-time by measuring precise distances between loci labelled with a pair of fluorophores, one of which emits light proportionate to thei