Role of the medial prefrontal cortex, striatum, and nucleus accumbens in the emission of 50-kHz ultrasonic vocalizations in hemiparkinsonian rats treated with dopaminergic drugs
Jacopo Marongiu, Giulia Costa, Nicola Simola, Marcello Serra · FENS Forum 2024
The prolonged use of dopamine replacement therapy (DRT) in Parkinson’s disease (PD) is associated with the onset of non-motor complications, including iatrogenic psychiatric-like disturbances. However, the preclinical investigation of the latter is limited, due to the lack of reliable animal models. In this regard, we developed a new model consisting in the evaluation of 50-kHz ultrasonic vocalizations (USVs), a behavioral marker of positive affect, in rats unilaterally lesioned with 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle and treated with either apomorphine or L-DOPA, two dr
ePoster · Neuroscience