Topic: Iba1+ microglia

Overconsumption of ultra-processed food and sedentary lifestyle are the main causes of obesity, which in turn, increases the risk of developing metabolic, cardiovascular, and psychiatric diseases. Loss of control over food intake and binge eating often worsen as obesity progresses. Many studies have shown the effect of obesity on gut-microbiota composition and inflammation. However, less is known about microbiota and central adaptations occurring during the initial phases of body weight gain. To address this question, we used a rat model of binge eating, in which, rats (C/P) were fed twice a w