Topic: ICI 118-551

The noradrenergic (NA) system plays a critical role in memory consolidation, including declarative memory. Recognition memory, an important aspect of declarative memory, involves the ability to acquire and recall information to identify familiar stimulus. Novel Object Recognition (NOR) is a widely used task to assess this type of memory in rodents. This test is based on the innate preference for novelty and the ability to discriminate novel and familiar objects. Post-training yohimbine administration, an a2-adrenoceptor antagonist, enhances object location memory in mice, suggesting that incre