Topic: IDO1

The kynurenine pathway of tryptophan metabolism is an important regulator of CNS neuroglial activity and immune system function. Here, novel factors influencing the kynurenine pathway (KP) are presented, with preliminary data examining links with TNF, a mediator known to have substantial clinical relevance. Bone-marrow derived macrophages (BMDMs), THP-1 and, RAW264.7 lines and mice lacking TNF receptor 1 (TNFR1) were used. Gene expression was assessed by qRT-PCR. Results showed that the bacterial serine protease subtilisin and mammalian prostate specific antigen (PSA) induced expression of IDO