Topic: IED waveform amplitude

Interictal epileptiform discharges (IEDs) are brief, sporadic, pathologic electrical bursts in the brains of patients with epilepsy. IEDs represent an important disease biomarker for tracking seizure risk and they also convey direct pathophysiological impacts including on cognitive function. While most work in human IED mechanisms has targeted the population-level neural activity using macro-electrode recordings, the single-neuron mechanisms of IEDs across the depth of human cortical lamina in vivo are largely unknown. We leveraged high-density Neuropixels probes to evaluate single-neuron acti