ePoster · Neuroscience
The sweet taste receptor signaling at primary cilia involves an adenylate cyclase inhibitory mechanism
Juan Villalobos, Maite Castro · FENS Forum 2024
The primary cilium, a microtubule-based organelle that extends into the extracellular space, plays a crucial role in signal transduction. It acts as an 'antenna' for signal conversion through different pathways, containing various types of proteins, such as G-protein-coupled receptors (GPCRs). Notably, it is involved in the regulation of glucose homeostasis, a vital process for cellular function and energy balance, which includes glucose detection associated with both metabolic (GLUTs and glucokinase) and independent mechanisms. Sweet taste receptors (STR), which are GPCRs composed of subunits