The pro-resolving effect of new FPR2 agonist on the evoked by bacterial endotoxin changes in microglia isolated from adult APP^NL-F/NL-F mice brains
Ewa Trojan, Jakub Frydrych, Enza Lacivita, Marcello Leopoldo, Agnieszka Bast-Kaim · FENS Forum 2024
INTRODUCTION: A lot of evidence demonstrates that Formyl-Peptide Receptor 2 (FPR2), fulfills various functions in the brain. Interestingly, based on agonist biased, this receptor can induce pro- and anti-inflammatory responses depending on the chemical structure of ligands. Recently, we have synthesized a new class of non-peptidic compounds that can activate.AIM: The present study aimed to determine the anti-inflammatory effect of FPR2 agonists: IG-4 in microglial cell cultures isolated from the brains of adult mice which are a human amyloid precursor protein (hAPP) knock-in mouse model of Alz
ePoster · Neuroscience