Understanding LZK-mediated reactive astrogliosis and neuronal repair using mouse molecular genetics and transcriptomic profiling
Kween Agba, Tiffany Gavin, Binhai Zheng · FENS Forum 2024
After spinal cord injury (SCI), astrocytes become reactive in a process called astrogliosis. These reactive astrocytes surround the lesion and form an astrocyte scar border. Our lab recently previously discovered that LZK (or MAP3K13) regulates reactive astrogliosis and scar formation after a dorsal spinal cord crush injury. The effect of LZK-mediated astrogliosis on neural repair and regeneration is still not clear. We aim to investigate this question utilizing genetically modified mice and RNA sequencing. We are testing the effect of astrocytic LZK overexpression or deletion on behavioral re
ePoster · Neuroscience