MMP-9 acts through IGF-I signaling pathway to promote dendritic spine plasticity
Diana Legutko, Grzegorz Olszak, Piotr Michaluk, Ryohei Yasuda, Leszek Kaczmarek · FENS Forum 2024
Understanding the intricate network of molecular interactions responsible for synaptic plasticity remains a significant challenge in neuroscience research. Matrix metalloproteinase-9 (MMP-9) has been repeatedly implicated in the plasticity of excitatory synapses, notably in proBDNF processing. Our current study extends these findings by elucidating MMP-9's crucial role in dendritic spine plasticity through its involvement in the insulin-like growth factor I receptor (IGFIR) signaling pathway. Specifically, we demonstrate that MMP-9 is essential for IGFIR activation, a key process in long-term
ePoster · Neuroscience