Passive transfer of IgG from patients with long-COVID neurological symptoms induces tactile allodynia in mice
Margaux Mignolet, Catherine Deroux, Kathleen De Swert, Valéry Bielarz, Fabienne George, Marc Jamoulle, Claire Diederich, Nicolas Gillet, Pierre Bulpa, Charles Nicaise · FENS Forum 2024
Between 15% and 30% of SARS-CoV-2-infected people still experience neurological symptoms (memory impairment, attention deficits, pain) more than 4 months after the onset of COVID-19. This condition, long-neuro-COVID, is poorly understood and might be explained by a persisting autoimmune response against nervous-derived self-antigens. This study aims to determine whether IgG autoantibodies from long-COVID patients can bind to central and peripheral nervous system epitopes and reproduce neuropsychiatric symptoms upon transfer into mice. Long-COVID patients meeting the consensus WHO definition we
ePoster · Neuroscience