An IgLON5 knockout mouse model results in mild behavioral alterations, without neurodegeneration
Ana Beatriz Serafim, Jon Landa, Mercedes Alba, Estibaliz Maudes, Laura Molina-Porcel, Anna Garcia-Serra, Francesco Mannara, Josep Dalmau, Francesc Graus, Lidia Sabater · FENS Forum 2024
Anti-IgLON5 is a rare neurological disorder characterized by brainstem dysfunction, abnormal movements, sleep alterations, autoantibodies against IgLON5, and neurodegeneration, sometimes with neuronal deposits of tau. IgLON5 is a neural cell adhesion molecule of unknown function. This study was aimed to determine the effects of loss of function of IgLON5 in a Knockout (IgLON5-KO) mouse model assessing brain morphology, social behavior, and symptoms.IgLON5-KO mouse was produced by CRISPR-Cas9 technology. Two-month-old IgLON5-KO and wild-type mice were subjected to a comprehensive battery of beh
ePoster · Neuroscience