N-methylpropargylamino-quinazoline derivatives as potential multi-target directed ligands in the therapy of Alzheimer's disease
Martin Horak, Anna Misiachna, Jan Konecny, Martin Kufa, Barbora Svobodova, Jan Korabecny · FENS Forum 2024
Alzheimer's disease (AD) is a complex ailment of uncertain origin. The available treatments, restricted to cholinesterase inhibitors and N-methyl-D-aspartate receptor (NMDAR) antagonists, merely relieve symptoms. Given the ineffectiveness of single-target therapies, a more promising approach involves a rational combination of specific targets into a single molecule, aiming to provide more significant benefits in mitigating symptoms and slowing disease progression. Our study focused on the design, synthesis, and biological evaluation of 24 new N-methylpropargylamino-quinazoline derivatives. Ini
ePoster · Neuroscience