ePoster · Neuroscience
Ex vivo direct current stimulation modulates synaptic plasticity under pathological condition with the implication of FKBP51-related signaling
Ching-Hsiang Chang, Ting-Yu Chung, Wan-Jou Lee, Jia-Yi Li, Yu-Feng Chen, Hui-Ching Lin · FENS Forum 2024
Dysregulation of synaptic plasticity was associated with numerous neurological disorders, including ischemic long-term potentiation (iLTP). Direct current stimulation (DCS) changes neuronal plasticity by the weak direct current which induces depolarization and hyperpolarization of resting membrane potential with opposite direction of polarity. FK506-binding protein 51 (FKBP51) is considered an important molecular pathway that modulates synaptic plasticity in such disease models. The correlation of the regulatory effects in plasticity under pathological condition facilitated by DCS and FKBP51 r