Dual inhibition of ecto-5'-nucleotidase (CD73) and adenosine A2A receptor reduces neuroinflammation and oxidative stress in TNF, IL-1α, C1q-induced neurotoxic astrocytes
Katarina Mihajlović, Marija Adžić Bukvić, Ivana Stevanović, Milorad Dragić, Nadežda Nedeljković · FENS Forum 2024
Ecto-5'-nucleotidase (CD73) is an ecto-enzyme that hydrolyzes adenosine monophosphate to adenosine, which acts through one of four subtypes of adenosine receptors. Increased CD73 activity and expression in chronic neurodegenerative diseases leads to a higher concentration of adenosine in the extracellular space. This results in excessive activation of adenosine A2AR, which triggers proinflammatory signaling pathways that further promote neurodegeneration. Therefore, dual CD73/A2AR inhibition is a potential pharmacologic target in chronic neurodegeneration. In the present study, we used a novel
ePoster · Neuroscience