Interleukin-33 as a player in axon remyelination in response to CNS and PNS injury
Małgorzata Zawadzka, Beata Kucharz, Katarzyna Konarzewska, Urszula Sławińska · FENS Forum 2024
Aims. Interleukin-33 is a protein enhancing Th2 cytokine production, initially described as an alarmin that is released from dying, necrotic cells to affect the immune response. Therefore, we aimed to examine the role of IL-33 in response to both CNS and PNS injury. Methods and Results. Using qPCR, Western blotting, and ELISA assay we showed significant up-regulation of IL-33 in two models of nervous system pathology in response to demyelination of the CNS white matter and sciatic nerve crush. We showed that IL-33 is produced exclusively by non-myelinating oligodendrocytes in the intact white
ePoster · Neuroscience