BACE1-dependent effects of IL-6 on cortical circuits
Buket Ucar Franke, Kai Kummer, Stefan Rose-John, Stefan F. Lichtenthaler, Michaela Kress · FENS Forum 2024
Pleiotropic cytokine IL-6 regulates various processes in the body including neuronal functions. IL-6 can signal through its membrane bound receptor IL-6R, which associates with IL-6 signal transducer gp130 IL-6st/gp130 (classical signaling), or binds to soluble IL-6R to act on any cell that that expresses IL-6st/gp130 (trans-signaling). Alzheimer’s disease related enzyme BACE1 has critically important roles in synaptic function and cleaves IL-6st/gp130 as well as IL-6R.Therefore, we hypothesize that BACE1 could be essential for the alteration of neuron excitability and synaptic plasticity via
ePoster · Neuroscience