Topic: immediate early gene cfos

The loss of memories is the earliest and often most detrimental symptom in the course of Alzheimer’s disease (AD), the most common form of dementia. The loss of neuronal cells, which are assumed to carry mnemonic information, suggests itself to be the leading cause of memory loss. Besides, the question of alternative mechanisms has been raised. Our lab recently showed that an additional cell ensemble, so-called novelty-like cells, interfered with the engram and thus, impaired memory recall. This suggests a novel mechanism of memory impairment. However, the exact circuit that leads to the evoca