Neuronal correlates of increased behavioral inhibition by interoceptive stimulation in a mouse model of autism spectrum disorder
Nino Kobakhidze, Simone B. Sartori, Sarah Gorkiewicz, Francesca Silvagni, Arnau Ramos-Prats, Claudia Claudia Schmuckermair, Pawel M. Matulewicz, Francesco Ferraguti, Gaia Novarino, Nicolas Singewald · FENS Forum 2024
The subjective experience of internal sensation processing (interoception) which affects emotions, appears to be altered in autism spectrum disorder (ASD) and anxiety disorders. Anxiety is a frequently co-occurring condition in patients with ASD, exacerbating ASD symptoms and causing functional impairments in these individuals. In contrast to anxiety in normotypic populations, our knowledge about the neuronal correlates of anxiety in ASD is very limited. Here we investigated behavioral responses to CO2 inhalation in Setd5 haploinsufficient (Setd5+/-) mice, which demonstrate signs of ASD and al
ePoster · Neuroscience