Association between a previously remembered context and an aversive experience is accompanied by repeated activations of the same context engram neurons throughout the brain
Olga Ivashkina, Ksenia Toropova, Konstantin Anokhin · FENS Forum 2024
The ability to form associations is one of the fundamental features of the brain. Pavlov's original work on classical conditioning employed CS that immediately preceded reinforcement. Here, using the model of context preexposure (Rudy, O'Reilly, 2001; Vorobieva et al., 2017), we studied how an engram of a distant past context can become a CS. Mice explored a new context, and then with different delays (from 30 minutes up to 30 days) received an immediate shock in the same environment. We showed that contextual memory engram can be conditioned at all tested intervals. We then used c-Fos express
ePoster · Neuroscience