Topic: immunoglobulin G

Spinal cord injury (SCI) results in the rupture of blood vessels and bleeding inside the spinal cord, as well as the release of alarmins from necrotic cells, leading to neuroinflammation and disruption of blood-spinal cord barriers. This increased permeability of the blood vessel walls allows for the entry of blood substances into the spinal cord parenchyma. Among these substances is immunoglobulin G (IgG). To understand the role of IgG, we performed immunofluorescence (IF) against IgG at 1 hour, 24 hours, and 7 days post-injury, both near and far from the lesion, in a mouse model of T9-T10 sp