Regionally distinct striatal circuits support broadly opponent aspects of action suppression and production
Bruno Cruz,Gonçalo Guiomar,Sofia Soares,Asma Motiwala,Christian Machens,Joseph J. Paton · COSYNE 2022
The direct and indirect pathways of the basal ganglia (BG) are classically thought to promote and suppress action, respectively. However, observed coactivation of neurons initiating the two pathways, striatal direct (dMSNs) and indirect (iMSNs) medium spiny neurons, has called this view into question. Here we study these circuits in mice performing an interval categorization task that requires a series of self-initiated and cued actions, and critically, a sustained period of dynamic action suppression. While movement produced similar activation of iMSNs and dMSNs in sensorimotor, dorsolateral
Sat, Mar 19, 2022