Neuropilin-mediated Sema 3 signaling is crucial for chick spinal cord neuroprogenitor cells to exit the cell cycle and protect early-born neurons from apoptosis
Rita Varga, Angelika Varga, Kirsten Roberts, Peter Szucs, Zoltan Meszar · FENS Forum 2024
After neurulation, neuroprogenitor cells differentiate into postmitotic neurons that migrate away from the ventricular zone and form a laminated structure in the spinal cord. Semaphorins are crucial for neuronal differentiation, particularly in axon pathfinding. Although semaphorin receptors are expressed in the ventricular zone of the developing spinal cord, their role in the neuronal cell cycle is not yet clear. Our study suggests that Sema 3 and their neuropilin receptors may be involved in a process that we disrupted using in-ovo electroporation. We overexpressed dominant-negative forms of
ePoster · Neuroscience