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Topic: in situ hybridization

ePoster
2 ePosters

In Neuroscience

Profiling non-coding RNA expression in brain tissue via in situ hybridization

Nirupama Chandel, Francesca Mazzoni, Hartmut Pohl, Jack Coleman · FENS Forum 2024

Aim: Over the past decade, our understanding of the transcriptional landscape in the brain has undergone a dogma-challenging expansion, revealing the intricate role of non-protein-coding RNAs (ncRNAs) in neural function, development, and disease. A large number of ncRNAs have been discovered and implicated in molecular regulatory processes involved in neural homeostasis and activity and seem to play crucial roles in neurodegenerative disorders and cancer. This study aims to assess the efficacy of in situ hybridization (ISH) in profiling long non-coding RNAs (lncRNAs) and circular RNAs (circRNA

ePoster · Neuroscience

Sensory channels of cardiac interoception

Nikolai Hoermann, Kristian Herrera, Leehealey Kennedy, Emma Nagler, Yasuko Isoe, Florian Engert, Mark Fishman · FENS Forum 2024

Interoception it has a large influence on how animals make decisions and is necessary to adjust internal body function to the organism’s needs, such as during rest or hunting. The heart is essential in the process to adapt the animal to changing circumstances by increasing or decreasing its rate. Heart rate modulation occurs through the communication between sensory and motor ganglia of the autonomic nervous system. The vagal neurons transmit information to the heart and send information via the autonomic nervous system to the central nervous system. How they interact to change heart activity,

ePoster · Neuroscience