Topic: in vitro neuronal systems

In this study we explore network connectivity of in vitro neuronal systems of live biological cells within a real-time game environment of the game Pong. We use DishBrain - a system that embodies in vitro neural networks with in silico computation using a high-density multi-electrode array (MEA). We compare functional connectivity across resting-state sessions and gameplay sessions, during which the cells control a paddle able to hit a ball. The location of the paddle and ball are temporally and spatially encoded and presented to the neurons via electrical stimulation. We observe significant d