Topic: In vivo 2-photon imaging

The hippocampus, necessary for the formation of new memories, undergoes experience-dependent synaptic plasticity. These Hebbian changes require synaptic homeostatic compensation to maintain the stability of neuronal systems. While functional and structural modifications have been demonstrated in cortical regions, little is known about how homeostasis affects the long-term structural stability of excitatory synapses in the hippocampus of live mammals. To answer these questions, we employed in vivo 2-photon imaging in mice to track long-term structural dynamics of dendritic spines (as a proxy fo