Targeting dysregulated long non-coding RNA expression as new therapeutic strategy in temporal lobe epilepsy
Theresa Auer, Morten T. Venø, Rory Johnson, David C. Henshall, Cristina Ruedell Reschke, Gary P. Brennan · FENS Forum 2024
Aims: Large-scale changes in epigenetic-mediated regulation of gene expression is known to drive the development of temporal lobe epilepsy (TLE) after a precipitating brain insult. Although long non-coding RNAs (lncRNAs) are key modulators of RNA processing, their functional involvement in epilepsy pathogenesis remains largely unexplored. Here, we perform the first comprehensive profiling study of lncRNAs during epileptogenesis and assess their utility as novel drug targets. Methods: To study lncRNA dysregulation, Next Generation Sequencing was performed on hippocampal tissue collected during
ePoster · Neuroscience