Topic: in vivo whole cell patch clamp recordings

Parkinson’s disease (PD) is characterized by the loss of dopamine in the basal ganglia (BG), particularly in the striatum, leading to aberrant activity patterns in BG neuronal circuits. The external globus pallidus (GPe) is a central nucleus in the BG and plays a pivotal role in the function of the indirect pathway. two populations of GPe cells were described, the prototypic and arkypallidal neurons, which are distinct developmentally, anatomically and electrophysiologically. Additionally, they have been shown to be involved in sensory processing, mediated by different input pathways. How dopa