Intrinsic biophysical properties and extrinsic spatial experience collaboratively prime CA1 pyramidal cells to replay during sharp-wave ripples
Xiaomin Zhang, Jules Auguste Lubetzki, Peter Jonas, Fritjof Helmchen · FENS Forum 2024
Episodic memory enables us to recall specific events from daily life, pinpointing when and where they occurred. However, newly encoded episodic memories are typically fragile due to constant interference with ongoing experiences and require consolidation to form long-lasting memories. This consolidation process involves the replay of neuronal ensembles encoding recent experiences during sharp-wave ripples (SWRs) in the hippocampus. While substantial evidence supports the functional significance of neuronal replay during SWRs for memory consolidation, the cellular mechanisms determining which n
ePoster · Neuroscience