Characterization of transgenic mouse lines overexpressing the ovine prion protein using well-defined scrapie and bovine spongiform encephalopathy strains
Olanrewaju Fatola, Markus Keller, Anne Balkema-Buschmann, James Olopade, Martin H. Groschup, Christine Fast · FENS Forum 2024
Transmissible spongiform encephalopathies, induced by the accumulation of the pathological prion protein (PrPSc), impact various species including scrapie in small ruminants and Bovine Spongiform Encephalopathy in cattle. The characterization of isolates has transitioned from conventional to transgenic mice, but standardization is not yet available for all models and strains. This study, therefore, aims to evaluate the strain typing efficacy of two transgenic mouse models (TgshpIX and TgshpXI), overexpressing ovine PrP (ARQ/ARQ), and compare them with results from the RIII wild-type model. We
ePoster · Neuroscience