Antioxidant effect of combined administration of metformin and propionate in a rat model of type 2 diabetes mellitus
Yuliia Osadchu, Larysa Natrus, Yuliia Klys, Timm Westhoff, Nina Babel, Moritz Anft · FENS Forum 2024
A lot of complications associated with type 2 diabetes mellitus (T2DM) are closely linked with the generation of reactive species or free radicals leading to oxidative/nitrosative stress. The aim of this study was to investigate the effect of combined administration of metformin with propionate on the degree of oxidative/nitrosative damage in the brain of rats with an experimental model of T2DM. Male Wistar rats were divided into control (healthy rats); rats with T2DM and no further therapy; rats with T2DM that received the following: metformin or propionate or propionate + metformin. Ventrome
ePoster · Neuroscience