The neurological consequences of peripheral inflammation: Delving into synaptic transmission and glial responses
Giorgia Scaringi, Bernadette Basilico, Luisa Seguella, Silvia Basili Franzin, Fabiana Laurette, Agnese Cherubini, Antonio Nussbaum, Ingrid Reverte, Laura Ferrucci, Giuseppe Esposito, Davide Ragozzino · FENS Forum 2024
Inflammatory bowel diseases (IBD) affect the gastrointestinal tract and can lead to extra-gut effects, including depression and anxiety related to the brain. Specifically, certain brain regions, such as the hippocampus, respond to bowel inflammation by modulating neuronal and glial activity. During the peak of inflammation, hippocampal regions undergo changes in glial properties that are associated with alterations in excitatory synaptic transmission. Additionally, bowel inflammation compromises the integrity of the blood-brain barrier, leading to the infiltration of immune cells and metabolit
ePoster · Neuroscience