Investigating the effects of chronic aerobic exercise on cognitive deficits and inflammatory markers in the sub-chronic phencyclidine mouse model for schizophrenia research
Katie Landreth, Mariam Huertas Radi, Michael Harte, John Gigg · FENS Forum 2024
Cognitive impairments associated with schizophrenia (CIAS) are modelled in rodents using sub-chronic administration of phencyclidine (scPCP). Changes to inflammatory markers have been associated with CIAS in patients, while exercise can improve cognition clinically and pre-clinically. This study aimed to investigate the effect of exercise on cognition and inflammation in the scPCP mouse.Adult female c57 mice were dosed with vehicle (0.9% saline, n=28) or PCP (10mg/kg, n=28) once daily for 10 days and divided into sedentary or exercised groups. Exercised mice had running-wheel access for 1h dai
ePoster · Neuroscience