Toward a comprehensive in vitro model of the human visual system: Three-dimensional assembloids integrating retinal and brain organoids
Ahmad Salti, Ammer-Pickhardt Franziska, Bellapianta Alessandro, Goureau Olivier, Bolz Matthias · FENS Forum 2024
The intricate development of the visual system involves spatial and temporal coordination, especially the projection of retinal ganglion cell (RGC) axons to post-synaptic targets in the brain. Although retinal organoids (ROs) have mimicked retinal development, their limitations in modeling RGC projections prompted the creation of in vitro assembloids integrating retinal and brain organoids. This study aims to elucidate the projection patterns of the human visual system of inherited retinal dystrophy (IRD) subjects and how this might influence RGC development and survival while providing answer
ePoster · Neuroscience