Targeted single-cell ablation uncovers network homeostasis of sound representations in mouse cortex
Takahiro Noda, Jens-Bastian Eppler, Matthias Kaschube, Simon Rumpel, Eike Kienle, Yonatan Loewenstein · COSYNE 2023
Sensory cortices maintain robust sensory representations despite an inevitable loss of neurons during aging and even during the prodromal stages of neurodegenerative diseases. However, the mechanisms that safeguard sensory representations and provide the cortical network with robustness against the loss of neurons are largely unknown. Here, we tested in how far the targeted elimination of functionally identified neurons affects the dynamics of sound-evoked population responses and could trigger homeostatic processes at the network level. We combined longitudinal two-photon calcium imaging of p
Sat, Mar 11, 2023