The selective deletion of an autism spectrum disorder associated gene in a neuronal subpopulation causes subtle anxiety-related abnormalities
Francesca Silvagni, Claudia Schmuckermair, Nino Kobakhidze, Sarah Gorkiewicz, Pawel Matulewicz, Arnau Ramos-Prats, Simone B. Sartori, Gaia Novarino, Nicolas Singewald, Francesco Ferraguti · FENS Forum 2024
Severe anxiety frequently co-occurs with core symptoms of autism spectrum disorders (ASD); however, the determinants are unexplored (Kerns et al., 2021). One of the most reliable anomalies reported in both ASD and anxiety disorder patients is an aberrant functional connectivity between the salience network and the default mode network (Uddin et al., 2015). Our data indicate that a specific inhibitory neuronal subpopulation plays a fundamental role in salience detection and in gating sensory stimuli to adaptively shape behavior. The aim of the project is to test whether failure in the encoding
ePoster · Neuroscience