Maternal consumption of a high-fat diet from pre-pregnancy to lactation impairs cognitive processes and inhibitory synaptic transmission of hippocampal neurons in mouse offspring
Camila Cerna, Nicole Vidal, Guillermo Rodríguez, Samanta Thomas, Marco Fuenzalida · FENS Forum 2024
Maternal obesity during pregnancy is a significant global health concern, impacting the metabolic, cardiovascular, and neurological health of the offspring, the latter being a research topic that has become of great interest. Our study investigates their effects on cognition, focusing on the hippocampus, a region vulnerable to prenatal insults. While maternal high-fat diet (mHFD) has been linked to cognitive deficits and hippocampal changes, its impact on synaptic transmission remains unexplored.Our focus was to understand how this adverse prenatal environment influences memory processes and w
ePoster · Neuroscience