Paraquat and 6-hydroxydopamine modulate nucleotide and nucleoside catabolism in zebrafish
Carla Denise Bonan, Josiane Woutheres Bortolotto, Stefani Altenhofen, Gabriela Madalena de Melo Martins, Giana de Paula Cognato, Carlos Eduardo Leite, Luiza Wilges Kist, Mauricio Reis Bogo · FENS Forum 2024
Parkinson's disease (PD) is considered the second most common neurodegenerative disease in the world. Animal models based on exposure to Paraquat (Pq) or 6-hydroxydopamine (6-OHDA) have been used to better understand and find new therapies for PD. Purinergic signaling has emerged as a pivotal factor in the progression of PD. We assessed the influence of Pq or 6-OHDA on ATP metabolism as well as nucleotide and nucleoside-metabolizing enzyme activities and gene expression in adult zebrafish brain. Adult zebrafish were injected i.p. with saline (vehicle) or Pq (10 or 20 mg/kg) with two days of in
ePoster · Neuroscience