Topic: input-output gain

Successful recovery after nervous system injury requires not only the restoration of damaged projections, but also appropriate processing of restored input by downstream circuits. How do target circuits adapt to such conditions of denervation and re-innervation? Might they undergo adaptive plastic modifications that promote functional repair and recovery? We addressed these questions by studying a unique model of naturally occurring regeneration in the adult mammalian brain. After a single dose of the olfactotoxin methimazole, olfactory sensory neurons in the nasal olfactory epithelium degener