Topic: inspiratory hypoxia

Hypoxia is increasingly seen as urgent physiological driving force, permitting cells within the brain and in other parts of the body to acclimate to lowered oxygen (O2) and reduced metabolism. The mediating transcription program is induced by inspiratory hypoxia but also by intensive motor-cognitive tasks, provoking a relative decrease in O2 in relation to the acutely augmented requirement. We named this essential, demand-dependent drop in O2 accessibility ′functional hypoxia′. Major players within the hypoxia reaction are hypoxia-inducible factors (HIF) and associated prolyl-hydroxylases. HIF