Topic: insulin-induced hypoglycaemia

Diabetes mellitus is a widespread disorder and hypoglycaemia is one of the most serious complications. The outcome might be influenced by several factors, such as the sex, previous fasting or the time of day when the episode occurs (see e.g. Somogyi effect). Our aim was to reveal these influencing factors using an insulin-induced hypoglycaemia model in Wistar rats.Fast-acting insulin (Novorapid, NR, 20NE/100g/0.2ml saline) or saline were injected intraperitoneally at the beginning of the light or dark phase (9am or 9pm) with or without 12h fasting. 60 minutes after intervention we collected tr