Topic: insulin metabolism

Orexin binds G-protein-coupled receptors, orexin receptor 1 (Ox1R) and 2 (Ox2R). These receptors modulate diverse brain functions, such as sleep and metabolism, with their wide expression throughout the brain. Previous in vitro studies have found that Ox2R works in both Gq and Gi-coupled signaling pathways, indicating excitatory and inhibitory functions respectively. In vivo studies, however, the inhibitory role has yet to be discerned, whereas the excitatory function has been elucidated in numerous reports. Consequently, Ox2R is predominantly recognized for eliciting only excitatory signals i