Diet-induced MAFLD: Unraveling liver-brain axis alterations and therapeutic potential of combined OLHHA and liraglutide treatment
Marialuisa de Ceglia, Ruben Tovar, Miguel Rodriguez-Pozo, Antonio Vargas, Ana Luisa Gavito, Carlo Cifani, Fernando Rodriguez de Fonseca, Juan Decara · FENS Forum 2024
Metabolic Associated Fatty Liver Disease (MAFLD) has recently emerged as a major health concern in Western countries, being characterized by hepatic fat accumulation, altered metabolism, increased oxidative stress, and inflammation. This condition triggers the release of hormones, free radicals, and inflammatory mediators in blood, potentially affecting central nervous system. Unfortunately, limited studies have explored the impact of MAFLD on the brain and its potential association with neuronal metabolism and activity. In our study, we utilized preclinical MAFLD model induced by a six-week e
ePoster · Neuroscience