Spiking neural network models of developmental frequency acceleration in the mouse prefrontal cortex
Gabriel Matias Lorenz, Sebastian Bitzenhofer, Mattia Chini, Pablo Martínez-Cañada, Ileana L. Hanganu-Opatz, Stefano Panzeri · FENS Forum 2024
The prefrontal cortex (PFC) exhibits prominent oscillatory activity already during early development. In the mouse PFC, these oscillations develop a beta band [15-30 Hz] component during the second postnatal week. These fast oscillations increase in frequency and amplitude with age until stabilizing in the adult-characteristic gamma band [30-80 Hz] during the fourth postnatal week. Abnormal development of fast prefrontal oscillations has been reported for mouse models of schizophrenia and autism. Here, we investigate potential drivers of PFC peak frequency acceleration through simulations of r
ePoster · Neuroscience