Early disruption in social recognition and its impact on episodic memory in triple transgenic mice model of Alzheimer’s disease
Anna Teruel-Sanchis, Manuel Esteban Vila-Martín, Camila Alexia Savarelli-Balsamo, Lorena Jiménez-Romero, Antonio García-de-León, Javier Zaplana-Gil, Joana Martinez-Ricos, Vicent Teruel-Martí, Enrique Lanuza-Navarro · FENS Forum 2024
In Alzheimer’s Disease (AD), memory deficits, particularly in spatial tasks, are well-documented. However, integrated memory encompassing both spatial and social information remains less explored. This study investigates early impairments in social recognition in the triple transgenic murine model of AD (3xTgAD) and correlates these deficits with the progression of AD pathology. Female 3xTgAD mice aged 2-4 and 6-8 months underwent a social recognition test, revealing significant impairments in recognizing non-familiar individuals by 6-8 months. Immunofluorescence assays for beta-amyloid and TA
ePoster · Neuroscience