Adhesion dynamics in the neocortex determine the start of migration and the post-migratory orientation of neurons
Elisa Pedersen, Ekaterina Epifanova, Valentina Salina, Denis Lajkó, Kathrin Textoris-Taube, Thomas Naumann, Olga Bormuth, Ingo Bormuth, Stephen Horan, Theres Schaub, Ekaterina Borisova, Mateusz C. Ambrozkiewicz, Victor Tarabykin, Marta Rosário · FENS Forum 2024
The neocortex is stereotypically organized into layers of excitatory neurons arranged in a precise parallel orientation. Here we show that dynamic adhesion both preceding and following radial migration is essential for this organization. Neuronal adhesion is regulated by the Mowat-Wilson syndrome-associated transcription factor Zeb2 (Sip1/Zfhx1b) through direct repression of independent adhesion pathways controlled by Neuropilin-1 (Nrp1) and Cadherin-6 (Cdh6). We reveal that to initiate radial migration, neurons must first suppress adhesion to the extracellular matrix. Zeb2 regulates the multi
ePoster · Neuroscience