PSD-95-dependent synaptic transmission in the dorsal CA1 area (dCA1) of the hippocampus is required for updating, but not formation, of contextual memories
Monika Puchalska, Magdalena Ziółkowska, Ahmad Salamian, Kasia Radwańska · FENS Forum 2024
It is widely believed that synaptic transmission in the hippocampus plays a crucial role in formation of contextual memories. Data obtained in our laboratory implies that PSD-95 (postsynaptic density protein 95)-dependent synaptic plasticity in dCA1 area is required for updating of contextual fear memory.To check how inactivation of dCA1 area affects contextual fear memory extinction, we stereotactically injected the adenoviral vectors (AAVs) encoding DREADD receptor hM4 [AAV2.1:hSyn_hM4_mCherry]. Next we trained mice in contextual fear conditioning (CFC). We found that chemogenetic inhibition
ePoster · Neuroscience