Exercise-based rescue strategies for early striatal synaptic impairment and motor abnormalities caused by alpha-synuclein
Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo, Elena Ferrari, Fabrizio Gardoni, Maria Emiliana Caristo, Barbara Picconi, Antonella Cardinale, Vittorio Loffredo, Francesco Cupri, Elvira De Leonibus, Maria Teresa Viscomi, Veronica Ghiglieri, Paolo Calabresi · FENS Forum 2024
Clinical and preclinical studies have shown that intensive exercise enhances BDNF production with neuroprotective action in health and disease conditions. Here we test the hypothesis that intensive exercise prevents corticostriatal alterations caused by α-syn protofibrils (PFFs) spreading through the nigrostriatal system in an early models of Parkinson’s disease (PD). To test this hypothesis, rats received striatal bilateral injection with phosphate buffer or PFF to study the link between α-syn, synaptic NMDA receptors (NMDAR) retention, and BDNF signaling. Animals were divided into two groups
ePoster · Neuroscience