Encoding of new and old memory during wake and quiescent states in a pharmacological model of psychosis by the NMDA receptor blocker MK-801
Karel Blahna Blahna, Frantisek Zitricky, Stepan Kapl, Athira Nataraj, Karel Jezek · FENS Forum 2024
The fundamental assumption of a functional system for encoding spatial information lies in the stability and preserved integrity of neural representations. In extreme cases, such as psychotic states in schizophrenia, there is a disruption of this stability, often resulting in the fusion of distinct neural representations. In this study, both familiar (F) and novel (N) linear mazes were utilized to assess the quality of neural coding across various time scales in 3-6 months old rats (N = 12). Lower (0.1 mg/kg) and higher doses (0.15 mg/kg) of MK-801 were administered. We observed disrupted spat
ePoster · Neuroscience